Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS004)
PSS Name	Affibody
Synonyms	Protein Z
Diagrammatic Sketch
Highest Status	Phase III
Class	Non-Antibody
Fold Type	Three Alpha-Helices
Thermal Denaturation TEMP	37-71℃
Sequence Length	58
Molecular Weight	6-19 kDa

Parental Protein of This PSS

Parental Protein Name	Synonym		PDB ID	UniProt ID	Origin
Protein A domain	Z-domain of staphylococcal protein A		2KZI	P38507	Staphylococcal; Synthetic construct

Synthetic Binding Protein (SBP) Featuring this PSS

SBP Name	Highest Status	Template	Expression System	Selection Method	Details	Ref
Affibody ABY-025	Phase III	N.A.	N.A.	N.A.	SBP Info	[1]
Affibody Izokibep	Phase II	N.A.	N.A.	N.A.	SBP Info	[2]
Affibody ABY-029	Phase I	N.A.	N.A.	N.A.	SBP Info	[3], [2]
Affibody anti-HER2 Z(HER2:41071)	Phase I	N.A.	N.A.	N.A.	SBP Info	[4], [5]
Affibody Tifalibep	Phase I; Discontinued	N.A.	N.A.	N.A.	SBP Info	[2]
Affibody anti-Abeta Z(SYM73)	Research	(Z(Abeta3A12))2	Escherichia coli BL21	staphylococcal platform;Flow cytometry	SBP Info	[6]
Affibody anti-CD276 AC12	Research	Affibody AC2	Escherichia coli	Yeast display and Fluorescence-activated cell sorting	SBP Info	[7]
Affibody anti-CD276 AC16	Research	Affibody AC2	Escherichia coli	Yeast display and Fluorescence-activated cell sorting	SBP Info	[7]
Affibody anti-CD276 AC9	Research	Affibody AC2	Escherichia coli	Yeast display and Fluorescence-activated cell sorting	SBP Info	[7]
Affibody anti-CD28 Z(CD28:5)	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[8]
Affibody anti-CD69 Z(CD69:10)	Research	N.A.	Escherichia coli BL21 (DE3)	Escherichia coli display	SBP Info	[9]
Affibody anti-CD69 Z(CD69:12)	Research	N.A.	Escherichia coli BL21 (DE3)	Escherichia coli display	SBP Info	[9]
Affibody anti-CD69 Z(CD69:2)	Research	N.A.	Escherichia coli BL21 (DE3)	Escherichia coli display	SBP Info	[9]
Affibody anti-CD69 Z(CD69:4)	Research	N.A.	Escherichia coli BL21 (DE3)	Escherichia coli display	SBP Info	[9]
Affibody anti-CD69 Z(CD69:6)	Research	N.A.	Escherichia coli BL21 (DE3)	Escherichia coli display	SBP Info	[9]
Affibody anti-CD69 Z(CD69:8)	Research	N.A.	Escherichia coli BL21 (DE3)	Escherichia coli display	SBP Info	[9]
Affibody anti-CTX-M-15 A50	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A51	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A511	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A52	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A529	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A545	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A546	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A5888	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-CTX-M-15 A59947	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (gammaDE3)	Ribosome display and Next generation sequencing	SBP Info	[10]
Affibody anti-DR5 ABY(DR5-6)	Research	ABY	Escherichia coli BL21 (DE3)	Phage display and Staphylococcal surface display	SBP Info	[11]
Affibody anti-EBV Z(EBV)12	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[12]
Affibody anti-EBV Z(EBV)132	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[12]
Affibody anti-EBV Z(EBV)137	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[12]
Affibody anti-EBV Z(EBV)142	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[12]
Affibody anti-EBV Z(LMP2A-N)110	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[13]
Affibody anti-EBV Z(LMP2A-N)252	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[13]
Affibody anti-EBV Z(LMP2A-N)85	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[13]
Affibody anti-EGFR Z(EGFR:1853)	Research	N.A.	Escherichia coli strain RRIM15	phage display	SBP Info	[14]
Affibody anti-EGFR Z(EGFR:1868)	Research	N.A.	Escherichia coli strain RRIM15	phage display	SBP Info	[14]
Affibody anti-EGFR Z(EGFR:1877)	Research	N.A.	Escherichia coli strain RRIM15	phage display	SBP Info	[14]
Affibody anti-EGFR Z(EGFR:1907)	Research	N.A.	Escherichia coli strain RRIM15	phage display	SBP Info	[14]
Affibody anti-EGFR Z(EGFR:1908)	Research	N.A.	Escherichia coli strain RRIM15	phage display	SBP Info	[14]
Affibody anti-EGFR ZB05	Research	N.A.	Staphylococcal carnosus	FACS	SBP Info	[15]
Affibody anti-ERBB3 Z(05405)	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display and Staphylococcal surface display	SBP Info	[16]
Affibody anti-ERBB3 Z(05413)	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display and Staphylococcal surface display	SBP Info	[16]
Affibody anti-ERBB3 Z(05416)	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display and Staphylococcal surface display	SBP Info	[16]
Affibody anti-ERBB3 Z(05417)	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display and Staphylococcal surface display	SBP Info	[16]
Affibody anti-Glycoprotein-G Z(RSV1)	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[17]
Affibody anti-HER2 Z(HER2:2395)	Research	N.A.	Escherichia coli BL21 (DE3)	N.A.	SBP Info	[4]
Affibody anti-HER2 Z(HER2:342)	Research	N.A.	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[4], [18]
Affibody anti-HER2 Z(HER2:4)	Research	N.A.	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[4], [18]
Affibody anti-HER2 Z(HER2:V2)	Research	N.A.	N.A.	N.A.	SBP Info	[4]
Affibody anti-Her3 ZHer3	Research	N.A.	Escherichia coli	N.A.	SBP Info	[19]
Affibody anti-HPV16 Z(HPV16)127	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[20]
Affibody anti-HPV16 Z(HPV16E7)301	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[20]
Affibody anti-HPV16 Z(HPV16E7)384	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[20]
Affibody anti-HPV16 Z(HPV16E7)745	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[20]
Affibody anti-IgA Z(IgA1)	Research	Z domain of staphylococcal protein A	Escherichia coli RV308	Phage display	SBP Info	[21]
Affibody anti-IL-6 ZIL-6_13	Research	N.A.	Escherichia coli	phage display	SBP Info	[22]
Affibody anti-Monoclonal antibody Z(mab22)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[23]
Affibody anti-Monoclonal antibody Z(mab22_25)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[23]
Affibody anti-Monoclonal antibody Z(mab25)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[23]
Affibody anti-PDGFRbeta Z01982	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[24]
Affibody anti-PDGFRbeta Z02465	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[24]
Affibody anti-PDGFRbeta Z02483	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[24]
Affibody anti-Raf-1 Z(RAF322)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[25]
Affibody anti-Raf-1 Z(RAF322: 01)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[25]
Affibody anti-Raf-1 Z(RAF322: 02)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[25]
Affibody anti-Raf-1 Z(RAF322: 03)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[25]
Affibody anti-Raf-1 Z(RAF322: 04)	Research	Z domain of staphylococcal protein A	Escherichia coli Rosetta (DE3)	Ribosome display	SBP Info	[25]
Affibody anti-SARS-CoV-2 M1	Research	N.A.	Escherichia coli BL21	mRNA Display	SBP Info	[26]
Affibody anti-SARS-CoV-2 Z14	Research	Zwt	N.A.	phage display	SBP Info	[27]
Affibody anti-SARS-CoV-2 Z149	Research	Zwt	N.A.	phage display	SBP Info	[27]
Affibody anti-SARS-CoV-2 Z171	Research	Zwt	N.A.	phage display	SBP Info	[27]
Affibody anti-SARS-CoV-2 Z327	Research	Zwt	N.A.	phage display	SBP Info	[27]
Affibody anti-SasA Z(SPA-1)	Research	Z domain of staphylococcal protein A	Escherichia coli	Phage display	SBP Info	[28]
Affibody anti-SasA ZpA963	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[29]
Affibody anti-Taq DNA polymerase Z(TaqS1-1)	Research	Z domain of staphylococcal protein A	Escherichia coli RV308	Phage display	SBP Info	[30]
Affibody anti-Taq DNA polymerase Z(TaqS10-7)	Research	Z domain of staphylococcal protein A	Escherichia coli RV308	Phage display	SBP Info	[30]
Affibody anti-TNF-alpha Z(TNF-alpha)1	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display; Staphylococcal surface display; Flow cytometry	SBP Info	[31]
Affibody anti-TNF-alpha Z(TNF-alpha)2	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	Phage display; Staphylococcal surface display; Flow cytometry	SBP Info	[31]
Affibody anti-ERBB1 Z(EGFR:955)	Research	IgG-binding B-domain of staphylococcal protein A analog Z	N.A.	Phage display	SBP Info	[32]
Affibody anti-ERBB3 Z(08698)	Research	N.A.	Escherichia coli Rosetta (DE3)	Staphylococcal surface display and Fluorescence-activated cell sorting	SBP Info	[33]
Affibody anti-ERBB3 Z(08699)	Research	N.A.	Escherichia coli Rosetta (DE3)	Staphylococcal surface display and Fluorescence-activated cell sorting	SBP Info	[33]
Affibody anti-FcRn/FcRn Z(FcRn_16)	Research	N.A.	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[34]
Affibody anti-FcRn/FcRn Z(FcRn_2)	Research	N.A.	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[34]
Affibody anti-FcRn/FcRn Z(FcRn_4)	Research	N.A.	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[34]
Affibody anti-fVIII Z(fVIII mat.?26)	Research	Z domain of staphylococcal protein A	N.A.	Phage display	SBP Info	[35]
Affibody anti-fVIII Z(fVIII mat.?28)	Research	Z domain of staphylococcal protein A	N.A.	Phage display	SBP Info	[35]
Affibody anti-fVIII Z(fVIII mat.?31)	Research	Z domain of staphylococcal protein A	N.A.	Phage display	SBP Info	[35]
Affibody anti-fVIII Z(fVIII:3)	Research	Z domain of staphylococcal protein A	N.A.	Phage display	SBP Info	[35]
Affibody anti-IgE clone Z	Research	N.A.	Staphylococcus carnosus	Staphylococcal surface display	SBP Info	[36]
Affibody anti-PD-L1 Z-j1	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	N.A.	SBP Info	[37]
Affibody anti-PD-L1 Z-j2	Research	Z domain of staphylococcal protein A	Escherichia coli BL21 (DE3)	N.A.	SBP Info	[37]
Affibody anti-rVIII Z(rVIII:3)	Research	Z domain of staphylococcal protein A	N.A.	Phage display	SBP Info	[35]
Affibody anti-Apo-A-1 clone 24:4	Research	Z domain of staphylococcal protein A	N.A.	N.A.	SBP Info	[38]
Affibody anti-ERBB1 Z(EGFR:1907)	Research	N.A.	N.A.	Phage display	SBP Info	[32]
Affibody anti-PDGFRbeta Z09591	Research	N.A.	Escherichia coli	N.A.	SBP Info	[39]

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