General Information of Synthetic Binding Protein (SBP) (ID: SBP000466)
SBP Name
Affibody anti-EBV Z(EBV)142
Synonyms
Affibody Z(EBV)142
Molecular Weight 6.5 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Sequence Length 58
SBP Sequence
>Affibody anti-EBV Z(EBV)142
VDNKFNKEALRARGEIAWLPNLNEEQDEAFIPSLHDDPSQSAELLAEAKKLNDAQAPK
3D Structure
Computationally Modelled Structure
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Template Name Z domain of staphylococcal protein A
Protein Scaffold Information of This SBP
Scaffold ID PS004
Scaffold Info
[1]
Scaffold Name Affibody
Scaffold Class Non-Antibody
Fold Type Three Alpha-Helices
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Latent membrane protein 2
BTS Info
Binder Nasopharyngeal carcinoma [ICD-11: 2B6B.Y] Kd: 1140 nM Wenzhou Medical University [1]
References
1 Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma. PLoS Pathog. 2020 Jan 6;16(1):e1008223.