General Information of Synthetic Binding Protein (SBP) (ID: SBP003508)
SBP Name
Affibody anti-IL-6 ZIL-6_13
Synonyms
Affibody ZIL-6_13
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method phage display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS004
Scaffold Info
[1]
Scaffold Name Affibody
Scaffold Class Non-Antibody
Fold Type Three Alpha-Helices
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Interleukin-6
BTS Info
Blocker Inflammatory disorders [ICD-11: 4A6Z] Kd: 0.5 nM AlbaNova University [1]
References
1 An affibody-adalimumab hybrid blocks combined IL-6 and TNF-triggered serum amyloid A secretion in vivo. MAbs. 2014;6(6):1598-607.