General Information of Synthetic Binding Protein (SBP) (ID: SBP003507)
SBP Name
Affibody anti-Her3 ZHer3
Synonyms
Affibody ZHer3
Molecular Weight 8.3 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Highest Status Research
Sequence Length 73
SBP Sequence
>Affibody anti-Her3 ZHer3
MRGSHHHHHHGSAEAKYAKEKYNAYYEIWQLPNLTKYQKAAFIGKLQDDPSQSSELLSEA
KKLNDSQAPKGSC
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS004
Scaffold Info
[1]
Scaffold Name Affibody
Scaffold Class Non-Antibody
Fold Type Three Alpha-Helices
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Epidermal growth factor receptor
BTS Info
binder Cancers [ICD-11: 2D4Z] N.A. Shandong First Medical University and Shandong Academy of Medical Sciences [1]
References
1 Her3-specific affibody mediated tumor targeting delivery of ICG enhanced the photothermal therapy against Her3-positive tumors. Int J Pharm. 2022 Apr 5;617:121609.