Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS017)
PSS Name	Bicyclic peptide
Synonyms	Synthetic bicyclic peptide; Dual-cyclic peptide
Diagrammatic Sketch
Highest Status	Phase II
Class	Non-Antibody
Fold Type	Loops
Thermal Denaturation TEMP	>37℃
Sequence Length	`10-30
Molecular Weight	1-3 kDa

Parental Protein of This PSS

Parental Protein Name	Synonym		PDB ID	UniProt ID	Origin
Peptide	N.A.		N.A.	N.A.	Plant; Bacteria

Synthetic Binding Protein (SBP) Featuring this PSS

SBP Name	Highest Status	Template	Expression System	Selection Method	Details	Ref
Bicyclic peptide BT1718	Phase II	N.A.	N.A.	N.A.	SBP Info	[1], [2]
Bicyclic peptide BT5528	Phase II	N.A.	N.A.	N.A.	SBP Info	[3], [4]
Bicyclic peptide BT7480	Phase II	N.A.	N.A.	Phage display	SBP Info	[5]
Bicyclic peptide BT8009	Phase II	N.A.	N.A.	N.A.	SBP Info	[6]
Bicyclic peptide anti-Grb7-SH2 G7-B10	Research	G7-B7	E.coli BL21 (DE3)	N.A.	SBP Info	[7]
Bicyclic peptide anti-Grb7-SH2 G7-B8	Research	G7-B7	E.coli BL21 (DE3)	N.A.	SBP Info	[7]
Bicyclic peptide anti-Grb7-SH2 G7-B9	Research	G7-B7	E.coli BL21 (DE3)	N.A.	SBP Info	[7]
Bicyclic peptide anti-Integrin BiRK-1	Research	N.A.	N.A.	N.A.	SBP Info	[8]
Bicyclic peptide anti-Integrin BiRK-2	Research	N.A.	N.A.	N.A.	SBP Info	[8]
Bicyclic peptide anti-KRAS B1	Research	N.A.	N.A.	N.A.	SBP Info	[9]
Bicyclic peptide anti-KRAS B2	Research	N.A.	N.A.	N.A.	SBP Info	[9]
Bicyclic peptide anti-KRAS B3	Research	N.A.	N.A.	N.A.	SBP Info	[9]
Bicyclic peptide anti-KRAS B4	Research	N.A.	N.A.	N.A.	SBP Info	[9]
Bicyclic peptide anti-KRAS B4-27	Research	B3	N.A.	N.A.	SBP Info	[10]
Bicyclic peptide anti-PSMA peptide 1	Research	N.A.	N.A.	Phage display	SBP Info	[11]
Bicyclic peptide anti-Grb7 clone B4	Research	N.A.	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[12]
Bicyclic peptide anti-EphA2 clone 6044	Research	N.A.	N.A.	Phage display	SBP Info	[3]
Bicyclic peptide anti-EphA2 clone 6065	Research	N.A.	N.A.	Phage display	SBP Info	[3]
Bicyclic peptide anti-EphA2 clone 6088	Research	N.A.	N.A.	Phage display	SBP Info	[3]
Bicyclic peptide anti-EphA2 clone 6099	Research	N.A.	N.A.	Phage display	SBP Info	[3]
Bicyclic peptide anti-G-actin A11	Research	N.A.	Living cells	N.A.	SBP Info	[13]
Bicyclic peptide anti-PKK PK100	Research	N.A.	Mammalian cells	N.A.	SBP Info	[14]
Bicyclic peptide anti-PKK PK115	Research	N.A.	Mammalian cells	N.A.	SBP Info	[14]
Bicyclic peptide anti-PKK PK128	Research	N.A.	Mammalian cells	N.A.	SBP Info	[14]
Bicyclic peptide anti-PKK PK15	Research	N.A.	Mammalian cells	N.A.	SBP Info	[14]
Bicyclic peptide anti-TNF-alpha M21	Research	N.A.	N.A.	Phage display	SBP Info	[15]
Bicyclic peptide anti-ALK4 B3	Research	N.A.	N.A.	N.A.	SBP Info	[16]
Bicyclic peptide anti-CD137 BT7401	Research	N.A.	N.A.	N.A.	SBP Info	[6]
Bicyclic peptide anti-EphA2/CD137 BT7455	Research	N.A.	N.A.	N.A.	SBP Info	[6]
Bicyclic peptide anti-ERBB1 cp23G	Research	N.A.	N.A.	N.A.	SBP Info	[17]
Bicyclic peptide anti-ERBB3 H33	Research	N.A.	N.A.	N.A.	SBP Info
Bicyclic peptide anti-Grb2 clone 1	Research	N.A.	N.A.	N.A.	SBP Info	[18]
Bicyclic peptide anti-Nectin-4/CD137 BT7480	Research	N.A.	N.A.	N.A.	SBP Info	[6]
Bicyclic peptide anti-Rab GTPase clone?25	Research	N.A.	N.A.	N.A.	SBP Info	[19]
Bicyclic peptide anti-TNF-alpha anticachexin C1	Research	N.A.	N.A.	N.A.	SBP Info	[20]
Bicyclic peptide anti-uPA UK18	Research	N.A.	N.A.	N.A.	SBP Info	[21]
Bicyclic peptide anti-uPA UK504	Research	N.A.	N.A.	N.A.	SBP Info	[22]

References

1	Bicyclic peptides: types, synthesis and applications. Drug Discov Today. 2019 Jun;24(6):1311-1319.
2	Bicycle therapeutics. AACR Annual meeting. Washington. 2017
3	Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads. J Med Chem. 2020 Apr 23;63(8):4107-4116.
4	MMAE Delivery Using the Bicycle Toxin Conjugate BT5528. Mol Cancer Ther. 2020 Jul;19(7):1385-1394.
5	BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist? (Bicycle TICA?) induces tumor localized CD137 agonism. J Immunother Cancer. 2021 Nov;9(11):e002883.
6	Bicycle therapeutics. Product Development Pipeline. 2021.
7	Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability. Biomedicines. 2022 May 16;10(5):1145.
8	Rational Design of a Dual-Targeting Natural Toxin-Like Bicyclic Peptide for Selective Bioenergetic Blockage in Cancer Cells. Bioconjug Chem. 2021 Oct 20;32(10):2173-2183.
9	Direct Ras Inhibitors Identified from a Structurally Rigidified Bicyclic Peptide Library. Tetrahedron. 2014 Oct 21;70(42):7714-7720.
10	Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor. J Med Chem. 2021 Sep 9;64(17):13038-13053.
11	The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody). J Biol Chem. 2021 Nov;297(5):101342.
12	Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep. 2016 Jun 3;6:27060.
13	Modulating dynamics and function of nuclear actin with synthetic bicyclic peptides. J Biochem. 2021 Apr 18;169(3):295-302.
14	Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases. ChemMedChem. 2012 Jul;7(7):1173-6.
15	Subunit disassembly and inhibition of TNF by a semi-synthetic bicyclic peptide. Protein Eng Des Sel. 2015 Feb;28(2):45-52.
16	Structure-based design of small bicyclic peptide inhibitors of Cripto-1 activity. Biochem J. 2020 Apr 30;477(8):1391-1407.
17	Toward a Novel Drug To Target the EGF-EGFR Interaction: Design of Metabolically Stable Bicyclic Peptides. Chembiochem. 2018 Jan 4;19(1):76-84.
18	A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake. Bioorg Med Chem. 2014 Nov 15;22(22):6387-91.
19	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides. Nat Commun. 2016 Apr 14;7:11300.
20	Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor- antagonist. J Am Chem Soc. 2013 Aug 14;135(32):11990-5.
21	Bicyclic peptide inhibitor reveals large contact interface with a protease target. ACS Chem Biol. 2012 May 18;7(5):817-21.
22	Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries. J Am Chem Soc. 2013 May 1;135(17):6562-9.