General Information of Synthetic Binding Protein (SBP) (ID: SBP003580)
SBP Name
Bicyclic peptide anti-PSMA peptide 1
Synonyms
Bicyclic peptide 1
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Phage display
Highest Status Research
Sequence Length 15
SBP Sequence
>Bicyclic peptide anti-PSMA peptide 1
Lys-Gly-Ser-Gly-Gly-Cys-Val-Tyr-Asp-Pro-Cys-Glu-Asp-Asp-Cys
Sequence Description TBMB is linked via three cysteine residues.
Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Glutamate carboxypeptidase 2
BTS Info
binder Research tool IC50: >50000 nM Charles University [1]
References
1 The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody). J Biol Chem. 2021 Nov;297(5):101342.