General Information of Synthetic Binding Protein (SBP) (ID: SBP000264)
SBP Name
Bicyclic peptide anti-uPA UK18
Synonyms
Bicyclic peptide UK18
Molecular Weight 1.8 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
PDB ID 3QN7
Sequence Length 17
SBP Sequence
>Bicyclic peptide anti-uPA UK18
ACSRYEVDCRGRGSACG
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Urokinase-type plasminogen activator
BTS Info
Inhibitor Research tool Kd: 157 nM Lausanne Federal Institute of Technology [1]
References
1 Bicyclic peptide inhibitor reveals large contact interface with a protease target. ACS Chem Biol. 2012 May 18;7(5):817-21.