Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00085)
BTS Name
Urokinase-type plasminogen activator
Synonyms
U-plasminogen activator; uPA; EC 3.4.21.73
BTS Type
Protein
Family
Peptidase S1 family
Gene Name
PLAU
Organism
Homo sapiens (Human)
Function
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
UniProt ID
P00749
UniProt Entry
UROK_HUMAN
PFam
PF00051 ; PF00089
Gene ID
5328
Sequence
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
Sequence Length
431
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Bicyclic peptide anti-uPA UK18 Research Inhibitor Kd: 157 nM Research tool
SBP Info
 		[1]
Bicyclic peptide anti-uPA UK504 Research Inhibitor N.A. Research tool
SBP Info
 		[2]
Fab anti-uPA BB7 Research Inhibitor Kd: 16 nM Research tool
SBP Info
 		[3]
Fab anti-uPA U33 Research Inhibitor Kd: 330 nM Research tool
SBP Info
 		[3]
Macrocyclic peptide anti-uPA clone 1 Research Inhibitor N.A. Research tool
SBP Info
 		[4]
Macrocyclic peptide anti-uPA mupain-1 Research Inhibitor Kd: 14100 nM Research tool
SBP Info
 		[4]
Macrocyclic peptide anti-uPA mupain-1-12 Research Inhibitor Kd: 1210 nM Research tool
SBP Info
 		[4]
Macrocyclic peptide anti-uPA mupain-1-16 Research Inhibitor Kd: 840 nM Research tool
SBP Info
 		[4]
References
1 Bicyclic peptide inhibitor reveals large contact interface with a protease target. ACS Chem Biol. 2012 May 18;7(5):817-21.
2 Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries. J Am Chem Soc. 2013 May 1;135(17):6562-9.
3 Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity. Biochim Biophys Acta Proteins Proteom. 2021 Feb;1869(2):140562.
4 Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors. Int J Biol Sci. 2017 Sep 21;13(10):1222-1233.