General Information of Synthetic Binding Protein (SBP) (ID: SBP003048)
SBP Name
Fab anti-uPA BB7
Synonyms
Fab BB7
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli BL21 (DE3)
Selection Method Phage display
Highest Status Research
SBP Sequence
>CDRL3
SARIEAPYA
>CDRH2
FIRSYAAGGTTD
Protein Scaffold Information of This SBP
Scaffold ID PS034
Scaffold Info
[1]
Scaffold Name Fab
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Urokinase-type plasminogen activator
BTS Info
Inhibitor Research tool Kd: 16 nM University of California San Francisco [1]
References
1 Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity. Biochim Biophys Acta Proteins Proteom. 2021 Feb;1869(2):140562.