General Information of Synthetic Binding Protein (SBP) (ID: SBP003419)
SBP Name
Bicyclic peptide anti-Grb7 clone B4
Synonyms
Bicyclic peptide G7-B4
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli BL21 (DE3)
Selection Method Phage display
Highest Status Research
PDB ID 5EEL; 5D0J
Sequence Length 9
SBP Sequence
>Bicyclic peptide anti-Grb7 clone B4
SFEGYDNSC
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Growth factor receptor-bound protein 7
BTS Info
Inhibitor Research tool Kd: 830 nM Monash University [1]
References
1 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep. 2016 Jun 3;6:27060.