Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00342)
BTS Name
Growth factor receptor-bound protein 7
Synonyms
B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein
BTS Type
Protein
Family
GRB7/10/14 family
Gene Name
GRB7
Organism
Homo sapiens (Human)
Function
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
UniProt ID
Q14451
UniProt Entry
GRB7_HUMAN
PFam
PF08947 ; PF00169 ; PF00788 ; PF00017
Gene ID
2886
Sequence
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR
ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA
GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG
SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG
FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG
SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS
LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY
LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Sequence Length
532
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Bicyclic peptide anti-Grb7 clone B4 Research Inhibitor Kd: 830 nM Research tool
SBP Info
 		[1]
Bicyclic peptide anti-Grb7-SH2 G7-B10 Research inhibitor Kd: 1150 nM Breast cancer [ICD-11: 2C6Z]
SBP Info
 		[2]
Bicyclic peptide anti-Grb7-SH2 G7-B8 Research inhibitor Kd: 860 nM Breast cancer [ICD-11: 2C6Z]
SBP Info
 		[2]
Bicyclic peptide anti-Grb7-SH2 G7-B9 Research inhibitor Kd: 2680 nM Breast cancer [ICD-11: 2C6Z]
SBP Info
 		[2]
References
1 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep. 2016 Jun 3;6:27060.
2 Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability. Biomedicines. 2022 May 16;10(5):1145.