Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003572) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Bicyclic peptide anti-Grb7-SH2 G7-B10
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| Synonyms |
Bicyclic peptide G7-B10
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| Molecular Weight | 1.4 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | E.coli BL21 (DE3) | |||||
| Highest Status | Research | |||||
| Sequence Length | 11 | |||||
| SBP Sequence |
>Bicyclic peptide anti-Grb7-SH2 G7-B10
KFEGYDNEFRC |
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| Sequence Description | The thioether linkage are tethering the N-terminal amine to the cysteine side chain and the lactam bridge that tethers Lys1 to Glu8 in the bicyclic peptide | |||||
| Template Name | G7-B7 | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS017 | [1] | ||||
| Scaffold Name | Bicyclic peptide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Growth factor receptor-bound protein 7 | inhibitor | Breast cancer [ICD-11: 2C6Z] | Kd: 1150 nM | Monash University | [1] | |