Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP002003) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Bicyclic peptide BT1718
|
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| Synonyms |
BT-1718
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Phase II | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS017 | [1] , [2] | ||||
| Scaffold Name | Bicyclic peptide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Matrix metalloproteinase-14 | Binder | Breast cancer [ICD-11: 2C6Z]; Lung cancer [ICD-11: 2C25.Z]; Endometrial cancer [ICD-11: 2C76.Z]; Bladder cancer [ICD-11: 2C94.Z]; Ovarian cancer [ICD-11: 2C73.Z] | Kd: 3 nM | Bicycle Therapeutics | [1] , [2] | |
| Clinical Trial Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| EUCTR2016-004633-24-GB | Click to show the Detail | |||||
| Indication | Advanced Solid Tumours. | |||||
| Phase | Phase I; Phase II | |||||
| Title | A Cancer Research UK Phase I/IIa trial of BT1718 (a Bicycle drug conjugate) given intravenously in patients with advanced solid tumours | |||||
| Status | Authorised | |||||
| Sponsor | Cancer Research UK | |||||
| NCT03486730 | Click to show the Detail | |||||
| Indication | Advanced Solid Tumours. | |||||
| Phase | Phase I; Phase II | |||||
| Title | A Cancer Research UK Phase I/IIa Clinical Trial of BT1718, (A Bicycle Drug Conjugate) Given Intravenously in Patients With Advanced Solid Tumours. | |||||
| Status | Recruiting | |||||
| Sponsor | Cancer Research UK | |||||