Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00086) | ||||||
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| BTS Name |
Matrix metalloproteinase-14
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| Synonyms |
MMP-14; EC 3.4.24.80; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP
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| BTS Type |
Protein
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| Family |
Peptidase M10A family
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| Gene Name |
MMP14
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| Organism |
Homo sapiens (Human)
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| Function |
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV |
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| Sequence Length |
582
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| Bicyclic peptide BT1718 | Phase II | Binder | Kd: 3 nM | Breast cancer [ICD-11: 2C6Z]; Lung cancer [ICD-11: 2C25.Z]; Endometrial cancer [ICD-11: 2C76.Z]; Bladder cancer [ICD-11: 2C94.Z]; Ovarian cancer [ICD-11: 2C73.Z] | [1], [2] | |
| Peptide aptamer anti-MT1-MMP Swiggle | Research | Binder | N.A. | Tools for protein function modulation | [3], [4] | |
| References |
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