Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000176)
SBP Name
Peptide aptamer anti-MT1-MMP Swiggle
Synonyms
Peptide aptamer Swiggle
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Human cells
Highest Status Research
SBP Sequence
>Inserted sequence
GGLIPCYFMH
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Matrix metalloproteinase-14
BTS Info
Binder Tools for protein function modulation N.A. University of Cambridge [1] , [2]
References
1 Peptide aptamers as new tools to modulate clathrin-mediated internalisation--inhibition of MT1-MMP internalisation. BMC Cell Biol. 2010 Jul 23;11:58.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.