Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003578) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Bicyclic peptide anti-KRAS B4
|
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| Synonyms |
Bicyclic peptide B4
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Research | |||||
| Sequence Length | 10 | |||||
| SBP Sequence |
>Bicyclic peptide anti-KRAS B4
Orn-Arg-nal-Arg-Fpa-Lys-phe-glu-Gly-Dap |
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| Sequence Description | The three-letter codes for L-amino acids have the first letter capitalized, whereas those of D-amino acids have all lower-case letters. | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS017 | [1] | ||||
| Scaffold Name | Bicyclic peptide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| GTPase KRas | inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 2.6 nM | Ohio State University | [1] | |