General Information of Synthetic Binding Protein (SBP) (ID: SBP000265)
SBP Name
Bicyclic peptide anti-PKK PK15
Synonyms
Bicyclic peptide PK15
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Mammalian cells
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Plasma kallikrein
BTS Info
Inhibitor Hereditary angioedema [ICD-11: 4A00.14] N.A. Lausanne Federal Institute of Technology [1]
References
1 Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases. ChemMedChem. 2012 Jul;7(7):1173-6.