General Information of Synthetic Binding Protein (SBP) (ID: SBP003579)
SBP Name
Bicyclic peptide anti-KRAS B4-27
Synonyms
Bicyclic peptide B4-27
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Sequence Length 15
SBP Sequence
>Bicyclic peptide anti-KRAS B4-27
PhiSNPhiPi-K-fQrR-J-SigmarFa-NH2
Sequence Description J = L-2,3-diaminopropionic acid; Pi = L-phenylglycine; Phi = D-2-napthylalanine; Sigma = L-ornithine
Template Name B3
Template Sequence Description The three-letter codes for L-amino acids have the first letter capitalized, whereas those of D-amino acids have all lower-case letters.
Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
GTPase KRas
BTS Info
Inhibitor Cancers [ICD-11: 2D4Z] IC50: 690 nM Ohio State University [1]
References
1 Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor. J Med Chem. 2021 Sep 9;64(17):13038-13053.