Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP003579) | ||||||
---|---|---|---|---|---|---|
SBP Name |
Bicyclic peptide anti-KRAS B4-27
|
|||||
Synonyms |
Bicyclic peptide B4-27
|
|||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Highest Status | Research | |||||
Sequence Length | 15 | |||||
SBP Sequence |
>Bicyclic peptide anti-KRAS B4-27
PhiSNPhiPi-K-fQrR-J-SigmarFa-NH2 |
|||||
Sequence Description | J = L-2,3-diaminopropionic acid; Pi = L-phenylglycine; Phi = D-2-napthylalanine; Sigma = L-ornithine | |||||
Template Name | B3 | |||||
Template Sequence Description | The three-letter codes for L-amino acids have the first letter capitalized, whereas those of D-amino acids have all lower-case letters. | |||||
Protein Scaffold Information of This SBP | ||||||
---|---|---|---|---|---|---|
Scaffold ID | PS017 | [1] | ||||
Scaffold Name | Bicyclic peptide | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Loops | |||||
Binding Target(s) of This SBP (BTS) |
---|
BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
---|---|---|---|---|---|---|
GTPase KRas | Inhibitor | Cancers [ICD-11: 2D4Z] | IC50: 690 nM | Ohio State University | [1] | |