Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003573)
SBP Name
Bicyclic peptide anti-Integrin BiRK-1
Synonyms
Bicyclic peptide BiRK-1
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Sequence Length 18
SBP Sequence
>Bicyclic peptide anti-Integrin BiRK-1
WRGDfVPKLM3KKLAKLKK-CONH2
Sequence Description M3, Trp and penultimate Lys form a bridge;M3 denotes l-propargylglycine
Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Integrin alpha-v-beta-3
BTS Info
binder Cancers [ICD-11: 2D4Z] N.A. Southwest Jiaotong University [1]
mitochondria
BTS Info
binder Cancers [ICD-11: 2D4Z] N.A. Southwest Jiaotong University [1]
References
1 Rational Design of a Dual-Targeting Natural Toxin-Like Bicyclic Peptide for Selective Bioenergetic Blockage in Cancer Cells. Bioconjug Chem. 2021 Oct 20;32(10):2173-2183.