Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000256) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Bicyclic peptide anti-EphA2 clone 6099
|
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| Synonyms |
BCY6099
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| Molecular Weight | 1.5-3 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| Sequence Length | 29 | |||||
| SBP Sequence |
>Bicyclic peptide anti-EphA2 clone 6099
[B-Ala][Sar][Sar][Sar][Sar][Sar][Sar][Sar][Sar][Sar][Sar]A[h omoarginine]DC[trans-4-hydroxyproline]LVNPLCLHP[d-Asp]W[homo arginine]C |
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| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS017 | [1] | ||||
| Scaffold Name | Bicyclic peptide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Ephrin type-A receptor 2 | Binder | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Kd: 5.7 nM | Babraham Research Campus | [1] | |