Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000262) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Bicyclic peptide anti-TNF-alpha M21
|
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| Synonyms |
Bicyclic peptide M21
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| Molecular Weight | 1.7 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| PDB ID | 4TWT | |||||
| Sequence Length | 12 | |||||
| SBP Sequence |
>Bicyclic peptide anti-TNF-alpha M21
ACPPCLWQVLCG |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS017 | [1] | ||||
| Scaffold Name | Bicyclic peptide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Tumor necrosis factor | Inhibitor | Inflammatory disorders [ICD-11: 4A6Z] | Kd: 13.5 nM | MRC Laboratory of Molecular Biology | [1] | |