General Information of Synthetic Binding Protein (SBP) (ID: SBP000263)
SBP Name
Bicyclic peptide anti-ALK4 B3
Synonyms
Bicyclic peptide B3
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Activin receptor type-1B
BTS Info
Binder Tumors [ICD-11: XH1N44] Kd: 62-168 nM Istituto di Biostrutture e Bioimmagini [1]
References
1 Structure-based design of small bicyclic peptide inhibitors of Cripto-1 activity. Biochem J. 2020 Apr 30;477(8):1391-1407.