Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003581) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Bicyclic peptide BT7480
|
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| Synonyms |
Bicyclic peptide BT7480
|
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| Molecular Weight | 7.2 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Phase II | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS017 | [1] | ||||
| Scaffold Name | Bicyclic peptide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| TNF receptor superfamily member 9 | binder | Cancers [ICD-11: 2D4Z] | Kd: 18 nM | Bicycle Therapeutics | [1] | |
| Nectin cell adhesion molecule 4 | binder | Cancers [ICD-11: 2D4Z] | Kd: 28 nM | Bicycle Therapeutics | [1] | |
| Nectin cell adhesion molecule 4 | binder | Cancers [ICD-11: 2D4Z] | Kd: 25 nM | Bicycle Therapeutics | [1] | |
| Nectin-4 | binder | Cancers [ICD-11: 2D4Z] | Kd: 6.7 nM | Bicycle Therapeutics | [1] | |
| Tumor necrosis factor receptor superfamily member 9 | binder | Cancers [ICD-11: 2D4Z] | Kd: 6.3 nM | Bicycle Therapeutics | [1] | |
| Nectin-4 | binder | Cancers [ICD-11: 2D4Z] | Kd: 12 nM | Bicycle Therapeutics | [1] | |
| Clinical Trial Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| NCT05163041 | Click to show the Detail | |||||
| Indication | Advanced Solid Tumor | |||||
| Phase | Phase I; Phase II | |||||
| Title | Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression | |||||
| Status | Recruiting | |||||
| Sponsor | BicycleTx Limited | |||||