Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00607) | ||||||
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| BTS Name |
Nectin-4
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| Synonyms |
Ig superfamily receptor LNIR; Nectin cell adhesion molecule; Poliovirus receptor-related protein 4
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| BTS Type |
Protein
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| Family |
nectin family
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| Gene Name |
Nectin4
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| Organism |
Mus musculus (Mouse)
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| Function |
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MPLSLGAEMWGPEAWLRLLFLASFTGQYSAGELETSDVVTVVLGQDAKLPCFYRGDPDEQ
VGQVAWARVDPNEGIRELALLHSKYGLHVNPAYEDRVEQPPPPRDPLDGSVLLRNAVQAD EGEYECRVSTFPAGSFQARMRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSV TWDTEVKGTQSSRSFTHPRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDRRITHTLQ VAFLAEASVRGLEDQNLWQVGREGATLKCLSEGQPPPKYNWTRLDGPLPSGVRVKGDTLG FPPLTTEHSGVYVCHVSNELSSRDSQVTVEVLDPEDPGKQVDLVSASVIIVGVIAALLFC LLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRSQPEESVGLRAEG HPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRTEEDDDQDEGIKQAM NHFVQENGTLRAKPTGNGIYINGRGHLV |
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| Sequence Length |
508
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Bicyclic peptide BT7480 | Phase II | binder | Kd: 6.7 nM | Cancers [ICD-11: 2D4Z] | [1] | |