Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00068) | ||||||
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| BTS Name |
Tumor necrosis factor receptor superfamily member 9
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| Synonyms |
4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD antigen CD137
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| BTS Type |
Protein
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| Gene Name |
TNFRSF9
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR
TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG CSCRFPEEEEGGCEL |
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| Sequence Length |
255
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Anticalin Cinrebafusp alfa | Phase I | Agonist | N.A. | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | [1], [] | |
| Bicyclic peptide anti-CD137 BT7401 | Research | Agonist | N.A. | Cancers [ICD-11: 2D4Z] | [2] | |
| Bicyclic peptide anti-EphA2/CD137 BT7455 | Research | Agonist | N.A. | Cancers [ICD-11: 2D4Z] | [2] | |
| Bicyclic peptide anti-Nectin-4/CD137 BT7480 | Research | Agonist | N.A. | Cancers [ICD-11: 2D4Z] | [2] | |
| Bicyclic peptide BT7480 | Phase II | binder | Kd: 6.3 nM | Cancers [ICD-11: 2D4Z] | [3] | |
| DARPin MP0310 | Phase I | Agonist | N.A. | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | [4], [5] | |
| References |
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