Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP002015) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
DARPin MP0310
|
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| Synonyms |
AMG506; AMG 506
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Phase I | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS027 | [1] , [2] | ||||
| Scaffold Name | DARPin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Tumor necrosis factor receptor superfamily member 9 | Agonist | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | N.A. | Molecular Partners; Amgen | [1] , [2] | |
| Prolyl endopeptidase FAP | Agonist | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | N.A. | Molecular Partners; Amgen | [1] , [2] | |
| Clinical Trial Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| NCT04049903 | Click to show the Detail | |||||
| Indication | Advanced Solid Tumor | |||||
| Phase | Phase I | |||||
| Title | A First-In-Human, Single-Arm, Multi-Center, Open-Label, Repeated-Dose, Dose-Escalation Study of MP0310 in Patients With Advanced Solid Tumors | |||||
| Status | Recruiting | |||||
| Sponsor | Molecular Partners | |||||