Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00087) | ||||||
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| BTS Name |
Nectin-4
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| Synonyms |
Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4
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| BTS Type |
Protein
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| Family |
Nectin family
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| Gene Name |
NECTIN4
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| Organism |
Homo sapiens (Human)
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| Function |
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; (Microbial infection) Acts as a receptor for measles virus.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ AMNHFVQENGTLRAKPTGNGIYINGRGHLV |
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| Sequence Length |
510
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Bicyclic peptide anti-Nectin-4/CD137 BT7480 | Research | Binder | N.A. | Cancers [ICD-11: 2D4Z] | [1] | |
| Bicyclic peptide BT7480 | Phase II | binder | Kd: 12 nM | Cancers [ICD-11: 2D4Z] | [2] | |
| Bicyclic peptide BT8009 | Phase II | Binder | N.A. | Breast cancer [ICD-11: 2C6Z]; Bladder cancer [ICD-11: 2C94.Z]; Pancreas cancer [ICD-11: 2C10.Z]; Lung cancer [ICD-11: 2C25.Z]; Esophageal cancer [ICD-11: 2B70.Z] | [1] | |