Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP002005) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Bicyclic peptide BT8009
|
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| Synonyms |
BT-8009
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Phase II | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS017 | [1] | ||||
| Scaffold Name | Bicyclic peptide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Nectin-4 | Binder | Breast cancer [ICD-11: 2C6Z]; Bladder cancer [ICD-11: 2C94.Z]; Pancreas cancer [ICD-11: 2C10.Z]; Lung cancer [ICD-11: 2C25.Z]; Esophageal cancer [ICD-11: 2B70.Z] | N.A. | Bicycle Therapeutics | [1] | |
| Clinical Trial Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| NCT04561362 | Click to show the Detail | |||||
| Indication | Nectin-4 Expressing Advanced Malignancies | |||||
| Phase | Phase I; Phase II | |||||
| Title | Phase I/II Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT8009 in Patients With Nectin-4 Expressing Advanced Malignancies | |||||
| Status | Recruiting | |||||
| Sponsor | Bicycle Tx Limited | |||||
| NCT06225596 | Click to show the Detail | |||||
| Indication | Metastatic Urothelial Cancer | |||||
| Phase | Phase II; Phase III | |||||
| Title | Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2) | |||||
| Status | Recruiting | |||||
| Sponsor | BicycleTx Limited | |||||