General Information of Binding Target of SBP (BTS) (ID: ST00609)
BTS Name
Nectin cell adhesion molecule 4
BTS Type
Protein
Family
nectin family
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
UniProt ID
A0A2K5WEQ6
UniProt Entry
A0A2K5WEQ6_MACFA
PFam
PF08205 ; PF13927 ; PF07686
Sequence
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
QVGQVAWARADAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
HVSFLAEASVRGLEDQNLWHVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQSEEPEGRSY
STLTTVREIETQTELLSPGSGRTEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYING
RGHLV
Sequence Length
485
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Bicyclic peptide BT7480 Phase II binder Kd: 28 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
References
1 BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist? (Bicycle TICA?) induces tumor localized CD137 agonism. J Immunother Cancer. 2021 Nov;9(11):e002883.