General Information of Synthetic Binding Protein (SBP) (ID: SBP000261)
SBP Name
Bicyclic peptide anti-G-actin A11
Synonyms
Bicyclic peptide A11
Molecular Weight 1.7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Living cells
Highest Status Research
Sequence Length 16
SBP Sequence
>Bicyclic peptide anti-G-actin A11
ACKSRLGCFMNNKSCG
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS017
Scaffold Info
[1]
Scaffold Name Bicyclic peptide
Scaffold Class Non-Antibody
Fold Type Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
G-actin
BTS Info
Modulator Tools for NLS-linked bicyclic peptides in the manipulation of dynamics and functions of nuclear actin Kd: 22 nM Tohoku University [1]
References
1 Modulating dynamics and function of nuclear actin with synthetic bicyclic peptides. J Biochem. 2021 Apr 18;169(3):295-302.