Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS064)
PSS Name
VL dAb
Synonyms
VL domain antibody; Synthetic VL
Diagrammatic Sketch
Highest Status Research
Class Antibody fragment
Fold Type Beta-Sheets + Loops
Thermal Denaturation TEMP 58-77℃
Sequence Length 106-133
Molecular Weight 11-18 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Ig kappa chain V-kappa
5XQY
P01627
Human; Rabbit; Synthetic structure
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
VL dAb anti-CEACAM6 VL383(SS)-1 Research VL383(SS) Escherichia coli TG1 Phage display
SBP Info
 		[1]
VL dAb anti-MBP VL(SS)-1 Research HVLP324(SS) Escherichia coli TG1 Phage display
SBP Info
 		[2]
VL dAb anti-MBP VL(SS)-2 Research HVLP324(SS) Escherichia coli TG1 Phage display
SBP Info
 		[2]
VL dAb anti-MBP VL(SS)-3 Research HVLP324(SS) Escherichia coli TG1 Phage display
SBP Info
 		[2]
VL dAb anti-MBP VL-1 Research HVLP324 Escherichia coli TG1 Phage display
SBP Info
 		[2]
VL dAb anti-MBP VL-2 Research HVLP324 Escherichia coli TG1 Phage display
SBP Info
 		[2]
VL dAb anti-MBP VL-3 Research HVLP324 Escherichia coli TG1 Phage display
SBP Info
 		[2]
VL dAb anti-MBP VL-4 Research HVLP324 Escherichia coli TG1 Phage display
SBP Info
 		[2]
VL dAb anti-MBP-intimin VL383(SS)-4 Research VL383(SS) Escherichia coli TG1 Phage display
SBP Info
 		[1]
VL dAb anti-MBP-intimin VL383(SS)-5 Research VL383(SS) Escherichia coli TG1 Phage display
SBP Info
 		[1]
VL dAb anti-MBP-intimin VL383(SS)-7 Research VL383(SS) Escherichia coli TG1 Phage display
SBP Info
 		[1]
VL dAb anti-TcdB VL B4 Research HVLP324 Escherichia coli TG1 Phage display
SBP Info
 		[3]
VL dAb anti-TcdB VL B5 Research HVLP324 Escherichia coli TG1 Phage display
SBP Info
 		[3]
VL dAb anti-B7.1 MB10 Research VL B10503 N.A. Phage display
SBP Info
 		[4]
VL dAb anti-HIV-1 D104 Research N.A. N.A. Phage display
SBP Info
 		[5]
VL dAb anti-HIV-1 F63 Research N.A. N.A. Phage display
SBP Info
 		[5]
References
1 Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V H/V L Single-Domain Antibodies from In Vitro Display Libraries. Front Immunol. 2017 Dec 12;8:1759.
2 A disulfide-stabilized human V L single-domain antibody library is a source of soluble and highly thermostable binders. Mol Immunol. 2017 Oct;90:190-196.
3 A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders. Protein Eng Des Sel. 2012 Jun;25(6):313-8.
4 Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains. J Mol Biol. 2001 Jul 13;310(3):591-601.
5 Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors. AIDS. 2016 Jul 17;30(11):1691-701.