Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS035)
PSS Name
Fynomer
Synonyms
Fyn SH3-based binder
Diagrammatic Sketch
Highest Status Phase II
Class Non-Antibody
Fold Type Beta-Sheets + Loops
Thermal Denaturation TEMP 70-74℃
Sequence Length 63-82
Molecular Weight 7-10 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Fyn tyrosine kinase SH3 domain SH3 domain of Fyn tyrosine kinase; SH3 domain(fyn kinase); FYN-SH3 domain; Fyn SH3
1M27
P06241
Human; Synthetic construct
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
Fynomer COVA 322 Phase II N.A. N.A. N.A.
SBP Info
 		[1]
Fynomer anti-BACE2 2B-H11 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[2]
Fynomer anti-Chymase 3C-B5 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-Chymase 3C-D7 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-Chymase 3C-E3 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-Chymase 3C-H2 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-Chymase 4C-A4 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-Chymase 4C-E4 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-Chymase C-F12 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-Chymase C-G2.3 Research Fyn SH3 Escherichia coli TG1 Phage display
SBP Info
 		[3]
Fynomer anti-ERBB3 C12 Research Fyn SH3 domain Chinese hamster ovary cells Phage display
SBP Info
 		[4]
Fynomer anti-IL-17A 2C1 Research Fyn SH3 domain Escherichia coli Phage display
SBP Info
 		[5]
Fynomer anti-FN clone D3 Research Fyn SH3 N.A. N.A.
SBP Info
 		[6]
References
1 In vitro-engineered non-antibody protein therapeutics. Protein Cell. 2018 Jan;9(1):3-14.
2 Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1124-37.
3 Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain. MAbs. Jul-Aug 2012;4(4):497-508.
4 A bispecific HER2-targeting FynomAb with superior antitumor activity and novel mode of action. Mol Cancer Ther. 2014 Aug;13(8):2030-9.
5 Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency. J Biol Chem. 2014 May 16;289(20):14392-8.
6 A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties. J Biol Chem. 2007 Feb 2;282(5):3196-204.