General Information of Synthetic Binding Protein (SBP) (ID: SBP001885)
SBP Name
Fynomer anti-Chymase C-F12
Synonyms
Fynomer C-F12
Molecular Weight 7.4 kDa
Thermal Denaturation TEMP 70 ℃
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli TG1
Selection Method Phage display
Highest Status Research
Sequence Length 65
SBP Sequence
>Fynomer anti-Chymase C-F12
GVTLFVALYDYRAERSTDLSFHKGEKFQILDMTVPNGDWWEARSLTTGETGYIPSNYVAP
VDSIQ
3D Structure
Computationally Modelled Structure
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Template Name Fyn SH3
Protein Scaffold Information of This SBP
Scaffold ID PS035
Scaffold Info
[1]
Scaffold Name Fynomer
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Chymase
BTS Info
Inhibitor Research tool Kd: 17.2 nM F. Hoffmann-La Roche Ltd [1]
References
1 Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain. MAbs. Jul-Aug 2012;4(4):497-508.