Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00178) | ||||||
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| BTS Name |
Chymase
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| Synonyms |
EC 3.4.21.39; Alpha-chymase; Mast cell protease I
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| BTS Type |
Protein
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| Family |
Peptidase S1 family;
Granzyme subfamily |
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| Gene Name |
CMA1
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| Organism |
Homo sapiens (Human)
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| Function |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI NQILQAN |
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| Sequence Length |
247
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Fynomer anti-Chymase 3C-B5 | Research | Inhibitor | Kd: 6.2 nM | Research tool | [1] | |
| Fynomer anti-Chymase 3C-D7 | Research | Inhibitor | Kd: 15.4 nM | Research tool | [1] | |
| Fynomer anti-Chymase 3C-E3 | Research | Inhibitor | Kd: 13.3 nM | Research tool | [1] | |
| Fynomer anti-Chymase 3C-H2 | Research | Inhibitor | Kd: 16.4 nM | Research tool | [1] | |
| Fynomer anti-Chymase 4C-A4 | Research | Inhibitor | Kd: 2.4 nM | Research tool | [1] | |
| Fynomer anti-Chymase 4C-E4 | Research | Inhibitor | Kd: 0.9 nM | Research tool | [1] | |
| Fynomer anti-Chymase C-F12 | Research | Inhibitor | Kd: 17.2 nM | Research tool | [1] | |
| Fynomer anti-Chymase C-G2.3 | Research | Inhibitor | Kd: 3.7 nM | Research tool | [1] | |
| Fynomer COVA 322 | Phase II | Binder | Kd: 0.9 nM | Plaque psoriasis [ICD-11: EA90.0] | [2] | |