General Information of Binding Target of SBP (BTS) (ID: ST00178)
BTS Name
Chymase
Synonyms
EC 3.4.21.39; Alpha-chymase; Mast cell protease I
BTS Type
Protein
Family
Peptidase S1 family;
Granzyme subfamily
Gene Name
CMA1
Organism
Homo sapiens (Human)
Function
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
UniProt ID
P23946
UniProt Entry
CMA1_HUMAN
PFam
PF00089
Gene ID
1215
Sequence
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
Sequence Length
247
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Fynomer anti-Chymase 3C-B5 Research Inhibitor Kd: 6.2 nM Research tool
SBP Info
[1]
Fynomer anti-Chymase 3C-D7 Research Inhibitor Kd: 15.4 nM Research tool
SBP Info
[1]
Fynomer anti-Chymase 3C-E3 Research Inhibitor Kd: 13.3 nM Research tool
SBP Info
[1]
Fynomer anti-Chymase 3C-H2 Research Inhibitor Kd: 16.4 nM Research tool
SBP Info
[1]
Fynomer anti-Chymase 4C-A4 Research Inhibitor Kd: 2.4 nM Research tool
SBP Info
[1]
Fynomer anti-Chymase 4C-E4 Research Inhibitor Kd: 0.9 nM Research tool
SBP Info
[1]
Fynomer anti-Chymase C-F12 Research Inhibitor Kd: 17.2 nM Research tool
SBP Info
[1]
Fynomer anti-Chymase C-G2.3 Research Inhibitor Kd: 3.7 nM Research tool
SBP Info
[1]
Fynomer COVA 322 Phase II Binder Kd: 0.9 nM Plaque psoriasis [ICD-11: EA90.0]
SBP Info
[2]
References
1 Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain. MAbs. Jul-Aug 2012;4(4):497-508.
2 In vitro-engineered non-antibody protein therapeutics. Protein Cell. 2018 Jan;9(1):3-14.