General Information of Synthetic Binding Protein (SBP) (ID: SBP001382)
SBP Name
Fynomer COVA 322
Synonyms
COVA322
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Phase II
Protein Scaffold Information of This SBP
Scaffold ID PS035
Scaffold Info
[1]
Scaffold Name Fynomer
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Chymase
BTS Info
Binder Plaque psoriasis [ICD-11: EA90.0] Kd: 0.9 nM Texas A&M University [1]
Clinical Trial Information of This SBP
NCT02243787 Click to show the Detail
Indication Stable Chronic Moderate-to-severe Plaque Psoriasis
Phase Phase I; Phase II
Title A Randomised, Double-blind, Sequential, Ascending Single-dose Study to Evaluate Safety, Tolerability, Biological Activity, and Systemic Exposure of?COVA322, a Bispecific TNF-alpha / IL-17A Antibody Fusion Protein, in Patients With Stable Chronic Moderate-to-severe Plaque Psoriasis
Status Terminated?(Safety Profile of COVA322)
Sponsor Covagen
References
1 In vitro-engineered non-antibody protein therapeutics. Protein Cell. 2018 Jan;9(1):3-14.