General Information of Synthetic Binding Protein (SBP) (ID: SBP001879)
SBP Name
Fynomer anti-Chymase 4C-E4
Synonyms
Fynomer 4C-E4
Molecular Weight 8.8 kDa
Thermal Denaturation TEMP 70 ℃
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli TG1
Selection Method Phage display
Highest Status Research
PDB ID 4AG1; 4AFZ
Sequence Length 78
SBP Sequence
>Fynomer anti-Chymase 4C-E4
MRGSGVTLFVALYDYNATRWTDLSFHKGEKFQILEFGPGDWWEARSLTTGETGYIPSNYV
APVDSIQGEQKLISEEDL
3D Structure
Experimentally Validated Structure
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Template Name Fyn SH3
Protein Scaffold Information of This SBP
Scaffold ID PS035
Scaffold Info
[1]
Scaffold Name Fynomer
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Chymase
BTS Info
Inhibitor Research tool Kd: 0.9 nM Roche Ltd [1]
References
1 Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain. MAbs. Jul-Aug 2012;4(4):497-508.