General Information of Synthetic Binding Protein (SBP) (ID: SBP001383)
SBP Name
Fynomer anti-FN clone D3
Synonyms
Fynomer D3
Molecular Weight 7.2 kDa
Thermal Denaturation TEMP 70.5 ℃
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Sequence Length 65
SBP Sequence
>Fynomer anti-FN clone D3
GVTLFVALYDYHAQSGADLSFHKGEKFQILKFGRGKGDWWEARSLTTGETGYIPSNYVAP
VDSIQ
3D Structure
Computationally Modelled Structure
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Template Name Fyn SH3
Protein Scaffold Information of This SBP
Scaffold ID PS035
Scaffold Info
[1]
Scaffold Name Fynomer
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Fibronectin
BTS Info
Binder Imaging agent for patients with solid tumor; Tools for delivering of toxic agents to the tumoral vasculature Kd: 85 nM Department of Chemistry and Applied Biosciences [1]
References
1 A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties. J Biol Chem. 2007 Feb 2;282(5):3196-204.