Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS016)
PSS Name
Beta-Hairpin mimetic
Synonyms
Polyphemusin II-based binder
Diagrammatic Sketch
Highest Status Phase III
Class Non-Antibody
Fold Type Beta-Sheets + Beta-Turn
Thermal Denaturation TEMP >29℃
Sequence Length `10-16
Molecular Weight 1-2 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Polyphemusin-2 Polyphemusin II N.A.
P14216
Horseshoe crab
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
beta-Hairpin mimetic Balixafortide Phase III N.A. N.A. N.A.
SBP Info
 		[1], [2]
beta-Hairpin mimetic Murepavadin Phase III N.A. N.A. N.A.
SBP Info
 		[3], [4], [5]
beta-Hairpin mimetic Lonodelestat Phase II N.A. N.A. N.A.
SBP Info
 		[6]
Beta-Hairpin mimetic anti-pre-miR-20b CPfox4 Research dPro-lPro template N.A. N.A.
SBP Info
 		[7]
Beta-Hairpin mimetic anti-pre-miR-20b CPfox7 Research dPro-lPro template N.A. N.A.
SBP Info
 		[7]
Beta-Hairpin mimetic anti-CXCR4 POL2438 Research N.A. N.A. N.A.
SBP Info
 		[8]
Beta-Hairpin mimetic anti-CXCR4 POL3026 Research N.A. N.A. N.A.
SBP Info
 		[8]
Beta-Hairpin mimetic anti-CXCR4 POL5551 Research N.A. N.A. N.A.
SBP Info
 		[3]
Beta-Hairpin mimetic anti-LptD L27-11 Research N.A. N.A. N.A.
SBP Info
 		[4]
Beta-Hairpin mimetic anti-LptD/BamA JB-95 Research N.A. N.A. N.A.
SBP Info
 		[4]
Beta-Hairpin mimetic anti-MDM2 clone?1 Research N.A. N.A. N.A.
SBP Info
 		[9]
Beta-Hairpin mimetic anti-MDM2 clone?2 Research N.A. N.A. N.A.
SBP Info
 		[9]
Beta-Hairpin mimetic anti-MDM2 clone?3 Research N.A. N.A. N.A.
SBP Info
 		[9]
Beta-Hairpin mimetic anti-MDM2 clone?4 Research N.A. N.A. N.A.
SBP Info
 		[9]
References
1 In vitro-engineered non-antibody protein therapeutics. Protein Cell. 2018 Jan;9(1):3-14.
2 DRUGBANK online. Balixafortide
3 Polyphor. Product Development Pipeline. 2021.
4 Protein Epitope Mimetics: From New Antibiotics to Supramolecular Synthetic Vaccines. Acc Chem Res. 2017 Jun 20;50(6):1323-1331.
5 DRUGBANK online. Murepavadin
6 alpha-Hairpin protein epitope mimetic technology in drug discovery. Drug Discov Today Technol. Spring 2012;9(1):e1-e70.
7 A Small Cyclic -Hairpin Peptide Mimics the Rbfox2 RNA Recognition Motif and Binds to the Precursor miRNA 20b. Chembiochem. 2019 Apr 1;20(7):931-939.
8 Discovery of novel, highly potent and selective beta-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles. Bioorg Med Chem. 2006 Dec 15;14(24):8396-404.
9 Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic -hairpins. Org Biomol Chem. 2016 Nov 8;14(44):10386-10393.