Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000584) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Beta-Hairpin mimetic anti-MDM2 clone?1
|
|||||
| Synonyms |
Beta-Hairpin mimetic clone?1
|
|||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Research | |||||
| Sequence Length | 10 | |||||
| SBP Sequence |
>Beta-Hairpin mimetic anti-MDM2 clone?1
P[d-Pro]FEWDL[Trp(Cl)]EF |
|||||
| Sequence Description | The first Pro and the last Phe form a bridge. | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS016 | [1] | ||||
| Scaffold Name | Beta-Hairpin mimetic | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Beta-Turn | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | Inhibitor | Tools for inhibiting the MDM2/p53 protein-protein interaction | Kd: 127 nM | University of Gothenburg | [1] | |