Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000580) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
beta-Hairpin mimetic Lonodelestat
|
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| Synonyms |
POL6014
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Phase II | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS016 | [1] | ||||
| Scaffold Name | Beta-Hairpin mimetic | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Beta-Turn | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Neutrophil elastase | Inhibitor | Cystic fibrosis [ICD-11: CA25.Z]; Alpha 1-antitrypsin deficiency [ICD-11: 5C5A]; Bronchiectasis [ICD-11: CA24] | N.A. | Santhera; Polyphor | [1] | |
| Clinical Trial Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| NCT03748199 | Click to show the Detail | |||||
| Indication | Cystic Fibrosis | |||||
| Phase | Phase I; Phase II | |||||
| Title | Phase-Ib/IIa Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Orally Inhaled Multiple Doses of?POL6014?in Patients With Cystic Fibrosis | |||||
| Status | Unknown | |||||
| Sponsor | Santhera Pharmaceuticals | |||||