Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00082) | ||||||
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| BTS Name |
Neutrophil elastase
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| Synonyms |
EC 3.4.21.37; Bone marrow serine protease; Elastase-2; Human leukocyte elastase; HLE; Medullasin; PMN elastase
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| BTS Type |
Protein
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| Family |
Peptidase S1 family;
Elastase subfamily |
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| Gene Name |
ELANE
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| Organism |
Homo sapiens (Human)
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| Function |
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN WIDSIIQRSEDNPCPHPRDPDPASRTH |
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| Sequence Length |
267
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| beta-Hairpin mimetic Lonodelestat | Phase II | Inhibitor | N.A. | Cystic fibrosis [ICD-11: CA25.Z]; Alpha 1-antitrypsin deficiency [ICD-11: 5C5A]; Bronchiectasis [ICD-11: CA24] | [1] | |
| Kunitz domain Depelstat | Phase II | Inhibitor | Kd: 0.001 nM | Cystic fibrosis [ICD-11: CA25.Z]; Acute respiratory distress syndrome [ICD-11: CB00] | [2], [3] | |
| References |
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