Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP000421) | ||||||
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SBP Name |
Kunitz domain Depelstat
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Synonyms |
DX-890
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Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Highest Status | Phase II | |||||
Template Name | BPTI | |||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS043 | [1] , [2] | ||||
Scaffold Name | Kunitz domain | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Alpha-Helices + Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Neutrophil elastase | Inhibitor | Cystic fibrosis [ICD-11: CA25.Z]; Acute respiratory distress syndrome [ICD-11: CB00] | Kd: 0.001 nM | Dyax; Debiopharm SA | [1] , [2] | |
Clinical Trial Information of This SBP | ||||||
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NCT00455767 | Click to show the Detail | |||||
Indication | Acute Respiratory Distress Syndrome | |||||
Phase | Phase II | |||||
Title | Phase IIA Multicenter 1 Week Treatment, Randomised, Double-Blind, Placebo Controlled Study of Depelestat in Patients Suffering From Acute Respiratory Distress Syndrome | |||||
Status | Completed | |||||
Sponsor | Debiopharm International SA | |||||