Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000586) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Beta-Hairpin mimetic anti-MDM2 clone?3
|
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| Synonyms |
Beta-Hairpin mimetic clone?3
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Research | |||||
| Sequence Length | 10 | |||||
| SBP Sequence |
>Beta-Hairpin mimetic anti-MDM2 clone?3
G[D-Pro]FSEDL[F(Br)]SF |
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| Sequence Description | The first Gly and the last Phe form a bridge. | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS016 | [1] | ||||
| Scaffold Name | Beta-Hairpin mimetic | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Beta-Turn | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | Inhibitor | Tools for inhibiting the MDM2/p53 protein-protein interaction | Kd: 5730 nM | University of Gothenburg | [1] | |