General Information of Synthetic Binding Protein (SBP) (ID: SBP000582)
SBP Name
Beta-Hairpin mimetic anti-pre-miR-20b CPfox4
Synonyms
Beta-Hairpin mimetic CPfox4
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
PDB ID 6DZA
Sequence Length 16
SBP Sequence
>Beta-Hairpin mimetic anti-pre-miR-20b CPfox4
EIIFNEAGSKRFRF[d-Pro]P
Sequence Description The first Glu and the last Pro form a bridge.
3D Structure
Experimentally Validated Structure
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Template Name dPro-lPro template
Protein Scaffold Information of This SBP
Scaffold ID PS016
Scaffold Info
[1]
Scaffold Name Beta-Hairpin mimetic
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Beta-Turn
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Precursor miRNA 20b
BTS Info
Binder Tools for mimicing Protein-protein interactions Kd: 50000 nM University of Washington [1]
References
1 A Small Cyclic -Hairpin Peptide Mimics the Rbfox2 RNA Recognition Motif and Binds to the Precursor miRNA 20b. Chembiochem. 2019 Apr 1;20(7):931-939.