Details of the PSS

Engineering of bispecific affinity proteins with high affinity for ERBB2 and adaptable binding to albumin. PLoS One. 2014 Aug 4;9(8):e103094.

Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3. Cell Mol Life Sci. 2013 Oct;70(20):3973-85.

Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G. Proteins. 2012 Mar;80(3):774-89.

Engineering bispecificity into a single albumin-binding domain. PLoS One. 2011;6(10):e25791.

p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells. Autoimmunity. 2017 Mar;50(2):102-113.

General Information of Protein Scaffold of SBP (PSS) (ID: PS001)
PSS Name	ABD-derived affinity protein
Synonyms	Albumin-binding domain variants; ABD variants; ADAPT
Diagrammatic Sketch
Highest Status	Research
Class	Non-Antibody
Fold Type	Three Alpha-Helices
Thermal Denaturation TEMP	49-80℃
Sequence Length	46
Molecular Weight	5-6 kDa

Parental Protein of This PSS

Parental Protein Name	Synonym		PDB ID	UniProt ID	Origin
Streptococcal Protein G	IgG-binding protein G		1IGC	P06654	Streptococcus sp. group G

Synthetic Binding Protein (SBP) Featuring this PSS

SBP Name	Highest Status	Template	Expression System	Selection Method	Details	Ref
ABD-derived affinity protein anti-ERBB2/HSA clone 1	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone 1(A43V)	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone 1(D6A)	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone 1(R14A)	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone 1(R35A)	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone 1(S3A)	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone 1(V15A)	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-10	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-12	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-12(A8)	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-17	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-18	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-4	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-5	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone mat1	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone mat3	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB2/HSA clone mat6	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display, Staphylococcal surface display and Flow cytomety	SBP Info	[1]
ABD-derived affinity protein anti-ERBB3/HSA clone 1	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display	SBP Info	[2]
ABD-derived affinity protein anti-ERBB3/HSA clone 13	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display	SBP Info	[2]
ABD-derived affinity protein anti-ERBB3/HSA clone 18	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display	SBP Info	[2]
ABD-derived affinity protein anti-ERBB3/HSA clone 2	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display	SBP Info	[2]
ABD-derived affinity protein anti-ERBB3/HSA clone 20	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display	SBP Info	[2]
ABD-derived affinity protein anti-ERBB3/HSA clone 27	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display	SBP Info	[2]
ABD-derived affinity protein anti-ERBB3/HSA clone 3	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display	SBP Info	[2]
ABD-derived affinity protein anti-IFNG clone 20	Research	Albumin-binding domain (ABD)	Escherichia coli BL21 (DE3)	Ribosome display	SBP Info	[3]
ABD-derived affinity protein anti-IFNG clone 223	Research	Albumin-binding domain (ABD)	Escherichia coli BL21 (DE3)	Ribosome display	SBP Info	[3]
ABD-derived affinity protein anti-IFNG clone 275	Research	Albumin-binding domain (ABD)	Escherichia coli BL21 (DE3)	Ribosome display	SBP Info	[3]
ABD-derived affinity protein anti-IFNG clone 29	Research	Albumin-binding domain (ABD)	Escherichia coli BL21 (DE3)	Ribosome display	SBP Info	[3]
ABD-derived affinity protein anti-IFNG clone 35	Research	Albumin-binding domain (ABD)	Escherichia coli BL21 (DE3)	Ribosome display	SBP Info	[3]
ABD-derived affinity protein anti-IFNG clone 40	Research	Albumin-binding domain (ABD)	Escherichia coli BL21 (DE3)	Ribosome display	SBP Info	[3]
ABD-derived affinity protein anti-TNF-alpha/HSA clone 1	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-TNF-alpha/HSA clone 2	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-TNF-alpha/HSA HT014	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-TNF-alpha/HSA HT015	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-TNF-alpha/HSA HT016	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-TNF-alpha/HSA T001	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-TNF-alpha/HSA T002	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-TNF-alpha/HSA T004	Research	Albumin-binding domain (ABD)	Escherichia coli	Phage display and Staphylococcal surface display	SBP Info	[4]
ABD-derived affinity protein anti-IL-23 clone ILP030	Research	Albumin-binding domain (ABD)	N.A.	Ribosome display	SBP Info	[5], [3]
ABD-derived affinity protein anti-IL-23 clone ILP317	Research	Albumin-binding domain (ABD)	N.A.	Ribosome display	SBP Info	[5], [3]
ABD-derived affinity protein anti-IL-23 clone ILP323	Research	Albumin-binding domain (ABD)	N.A.	Ribosome display	SBP Info	[5], [3]

References