Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP000348) | ||||||
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SBP Name |
ABD-derived affinity protein anti-ERBB2/HSA clone FACS-18
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Synonyms |
ADAPT(ERBB2-FACS-18)
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Molecular Weight | 5.2 kDa | |||||
Thermal Denaturation TEMP | 49 ℃ | |||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Escherichia coli | |||||
Selection Method | Phage display, Staphylococcal surface display and Flow cytomety | |||||
Highest Status | Research | |||||
Sequence Length | 46 | |||||
SBP Sequence |
>ABD-derived affinity protein anti-ERBB2/HSA clone FACS-18
LAPAKETALYHLDRIGVSDYYKDLIDKAKTVEGVRALYLEILRALP |
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3D Structure | ||||||
Computationally Modelled Structure | ||||||
Click to Save PDB File | ||||||
Template Name | Albumin-binding domain (ABD) | |||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS001 | [1] | ||||
Scaffold Name | ABD-derived affinity protein | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Three Alpha-Helices | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Receptor tyrosine-protein kinase erbB-2 | Binder | Cancers [ICD-11: 2D4Z] | Kd: 1.7 nM | KTH Royal Institute of Technology | [1] | |
Albumin | Binder | Cancers [ICD-11: 2D4Z] | Kd: 1 nM | KTH Royal Institute of Technology | [1] | |