Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000338) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
ABD-derived affinity protein anti-ERBB2/HSA clone 1(D6A)
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| Synonyms |
ADAPT(ERBB2-1) (D6A)
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| Thermal Denaturation TEMP | 72 ℃ | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Selection Method | Phage display, Staphylococcal surface display and Flow cytomety | |||||
| Highest Status | Research | |||||
| Template Name | Albumin-binding domain (ABD) | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS001 | [1] | ||||
| Scaffold Name | ABD-derived affinity protein | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Three Alpha-Helices | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Receptor tyrosine-protein kinase erbB-2 | Binder | Cancers [ICD-11: 2D4Z] | Kd: 148 nM | KTH Royal Institute of Technology | [1] | |
| Albumin | Binder | Cancers [ICD-11: 2D4Z] | Kd: 1.7 nM | KTH Royal Institute of Technology | [1] | |