Details of the BTS | SYNBIP

General Information of Binding Target of SBP (BTS) (ID: ST00449)
BTS Name	Src-homology 2 domain-containing phosphatase 2
Synonyms	SHP2
BTS Type	Protein
Organism	Homo sapiens (Human)

Synthetic Binding Protein (SBP) Targeting This BTS

SBP Name	Highest Status	Mechanism	Affinity	Application	Details	Ref
Monobody anti-SHP2 CS1	Research	Inhibitor	Kd: 44 nM	Research tool	SBP Info	[1], [2]
Monobody anti-SHP2 CS3	Research	Inhibitor	Kd: 48 nM	Chronic myeloid leukaemia [ICD-11: 2B33.2]	SBP Info	[2]
Monobody anti-SHP2 CS4	Research	Inhibitor	Kd: 20 nM	Chronic myeloid leukaemia [ICD-11: 2B33.2]	SBP Info	[2]
Monobody anti-SHP2 NSa1	Research	Inhibitor	Kd: 73 nM	Chronic myeloid leukaemia [ICD-11: 2B33.2]	SBP Info	[1], [2]
Monobody anti-SHP2 NSa2	Research	Inhibitor	Kd: 170 nM	Chronic myeloid leukaemia [ICD-11: 2B33.2]	SBP Info	[2]
Monobody anti-SHP2 NSa4	Research	Inhibitor	Kd: 32 nM	Chronic myeloid leukaemia [ICD-11: 2B33.2]	SBP Info	[2]
Monobody anti-SHP2 NSa5	Research	Inhibitor	Kd: 54 nM	Chronic myeloid leukaemia [ICD-11: 2B33.2]	SBP Info	[2]
Monobody anti-SHP2-SH2 aCS3	Research	Inhibitor	Kd: 4 nM	Research tool	SBP Info	[3]
Monobody anti-SHP2-SH2 aNSa1	Research	Inhibitor	Kd: 14 nM	Research tool	SBP Info	[3]
Monobody anti-Yes-SH2/Src-SH2 clone 1	Research	Inhibitor	Kd: 1129 nM	Tools for dissecting SFK functions in normal development and signaling	SBP Info	[4]

References

1	Monobodies and other synthetic binding proteins for expanding protein science. Protein Sci. 2017 May;26(5):910-924.
2	Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14924-9.
3	Targeting endogenous proteins for degradation through the affinity-directed protein missile system. Open Biol. 2017 May;7(5):170066.
4	Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J Mol Biol. 2017 May 5;429(9):1364-1380.