Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001294)
SBP Name	Monobody anti-SHP2 NSa4
Synonyms	Monobody NSa4
Molecular Weight	10.0 kDa
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Human embryonic kidney?cells 293; K562 Cells
Selection Method	Yeast display
Highest Status	Research
Sequence Length	91
SBP Sequence	>Monobody anti-SHP2 NSa4 VSDVPRDLEVVAATPTSLLISWDAPAVTVDYYVITYGETGYYAYFQEFEVPGSKSTATIS GLKPGVDYTITVYAAGYGYYYGNPISINYRT
3D Structure
	Computationally Modelled Structure
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Template Name	Fibronectin type III domain (FN3)

Protein Scaffold Information of This SBP
Scaffold ID	PS047 Scaffold Info					[1]
Scaffold Name	Monobody
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Src-homology 2 domain-containing phosphatase 2	BTS Info	Inhibitor	Chronic myeloid leukaemia [ICD-11: 2B33.2]	Kd: 32 nM	University of Chicago	[1]

References

1

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14924-9.