General Information of Synthetic Binding Protein (SBP) (ID: SBP001258)
SBP Name
Monobody anti-SHP2-SH2 aNSa1
Synonyms
Monobody aNSa1
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS047
Scaffold Info
[1]
Scaffold Name Monobody
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Src-homology 2 domain-containing phosphatase 2
BTS Info
Inhibitor Research tool Kd: 14 nM Medical Research Council Protein Phosphorylation and Ubiquitylation Unit [1]
References
1 Targeting endogenous proteins for degradation through the affinity-directed protein missile system. Open Biol. 2017 May;7(5):170066.